Characterization of beta-lactamase gene blaPER-2, which encodes an extended-spectrum class A beta-lactamase
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چکیده
منابع مشابه
Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae.
We biochemically characterized the Klebsiella pneumoniae extended-spectrum SHV-55 enzyme carrying the amino acid substitutions Tyr73Phe (as in SHV-28) and Gly2383Ser and Glu2403Lys (both found in SHV-5) identified in a previous study (5). The SHV-55 extended-spectrum -lactamase differed from SHV-5 only in the signal peptide region (1). The blaSHV-55 gene was obtained as described by Mendonça et...
متن کاملExtended-spectrum beta-lactamase-producing organisms.
Extended-spectrum beta-lactamases (ESBLs), which hydrolyse extended-spectrum cephalosporins and are inhibited by clavulanic acid, are spreading among Enterobacteriaceae. The CTX-M enzymes are replacing SHV and TEM enzymes as the prevalent type of ESBLs, principally in community-acquired infections caused by Escherichia coli. Associated infectious syndromes include mainly urinary tract infection...
متن کاملCharacterization of a chromosomally encoded extended-spectrum class A beta-lactamase from Kluyvera cryocrescens.
A chromosomally located beta-lactamase gene, cloned and expressed in Escherichia coli from a reference strain of the enterobacterial species Kluyvera cryocrescens, encoded a clavulanic acid-inhibited Ambler class A enzyme, KLUC-1, with a pI value of 7.4. KLUC-1 shared 86% amino acid identity with a subgroup of plasmid-mediated CTX-M-type extended-spectrum beta-lactamases (CTX-M-1, -3, -10, -11,...
متن کاملBiochemical-genetic characterization of the chromosomally encoded extended-spectrum class A beta-lactamase from Rahnella aquatilis.
From whole-cell DNA of a clinical isolate of the enterobacterial species Rahnella aquatilis, a beta-lactamase gene was cloned that encoded a chromosomally encoded Ambler class A enzyme, RAHN-1. RAHN-1, with a pI of 7.2, shares 76, 73, and 71% amino acid identity with the extended-spectrum beta-lactamase of chromosomal origin from Serratia fonticola and with the plasmid-mediated beta-lactamases ...
متن کاملHigh Prevalence of CTXM-15 Type Extended-Spectrum Beta-Lactamase Among Clinical Isolates of Klebsiella Pneumoniae
Background: Production of β–lactamases by enterobacteriacea, especially Klebsiella pneumoniae, is one of the emerging health problems in the world. The purpose of this study was to assess the frequency of blaCTX-M15 gene in K. pneumoniae isolates and determine the molecular diversity of CTXM producing isolates. Methods: In...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1996
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.40.3.616